Later she commented on her success, saying, "I think it's funny when people say I'm an overnight sensation, because I've been working at it for 10 years." She also starred opposite Michael Douglas and Kiefer Sutherland in the 2006 thriller The Sentinel, which was her first major role in a theatrical feature movie.
From 2015 to 2016, Longoria starred as Ana Sofia Calderón on the short-lived NBC sitcom Telenovela, and served as an executive producer for the Lifetime television series Devious Maids.
She has also served as an executive producer of social issue documentaries, including Food Chains and The Harvest.
She currently holds modeling contracts with L'Oréal and New York & Co, among others.
She received her master's degree in Chicano Studies from California State University, Northridge, in May 2013 following three years of study.
In the 2000s, Longoria appeared in several high-profile advertising campaigns and numerous men's magazines, reaching No. She was also featured on the cover of various international women's magazines, including Vogue, Marie Claire and Harper's Bazaar.
Longoria continues to be included in lists of Hollywood's Most Beautiful. 1 in Maxim's Hottest Female Stars of 20, becoming the first woman to top the list in two consecutive years.
She is also an executive producer of the documentaries The Harvest and Food Chains, for which she won a James Beard Foundation Award.
In March 2008, Longoria opened the restaurant Beso (which means "kiss" in Spanish) in Hollywood, along with partner and celebrity chef Todd English.
From 2013, she served as one of the executive producers of Devious Maids and directed the season two premiere, "An Ideal Husband".
In 2016, she also starred in the fourth season, in the episode "Once More Unto the Bleach".
According to Longoria, "because of my involvement with the NCLR and my charity work, I really wanted a better, more authentic understanding of what my community has gone through so I can help create change." In October 2012, Longoria spoke at the Mc Afee Focus 2012 event, where the "theme of safety—beyond computers—emerged.